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标题:Simulation Modelling in Ophthalmology: Application to Cost Effectiveness of Ranibizumab and Aflibercept for the Treatment of Wet Age-Related Macular Degeneration in the United Kingdom.
时间:2019-06-12 18:20:39
DOI:10.1007/s40273-016-0459-z
PMID:27787744
作者:Lindsay Claxton;Robert Hodgson;Matthew Taylor;Bill Malcolm;Ruth Pulikottil Jacob
出版源: 《Pharmacoeconomics》 ,2017 ,35 (2) :1-12
摘要:Simulation Modelling in Ophthalmology: Application to Cost Effectiveness of Ranibizumab and Aflibercept for the Treatment of Wet Age-Related Macular Degeneration in the United KingdomAbstract Background Previously developed models in ophthalmology have generally used a Markovian structure. There are a number of limitations with this approach, most notably the ability to base ...
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目录:
  • Simulation Modelling in Ophthalmology: Application to Cost Effectiveness of Ranibizumab and Aflibercept for the Treatment of Wet Age-Related Macular Degeneration in the United Kingdom
    • Abstract
      • Background
      • Objective
      • Methods
      • Results
      • Conclusions
    • Introduction
      • Background
      • Study Objectives
    • Methods
      • Overview
      • Modelling Approach
      • Patient Population
      • Model Parameters
        • Clinical Effectiveness
        • Quality of Life
        • Costs and Resource Use
        • Mortality
      • Validation
      • Analysis
    • Results
      • First-Order (Individual Patient) Uncertainty: Base-Case Analysis
      • Second-Order (Parameter) Uncertainty: Probabilistic Sensitivity Analysis
      • Visual Acuity
    • Discussion
      • Overview
      • Limitations
      • Strengths
      • Previous Economic Analyses in Ophthalmology
      • Conclusions
    • Acknowledgements
    • References

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