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标题:Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model.
时间:2019-06-12 17:10:12
DOI:10.1007/s13346-018-0523-7
PMID:29654411
作者:María Florencia Sanchez;Susana Andrea Breda;Elio Andrés Soria;Luis Ignacio Tártara;Rubén Hilario Manzo
出版源: 《Drug Delivery & Translational Research》 ,2018 (5) :1-14
摘要:Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn modelAbstract The purpose of this work was to develop an effective carbomer hydrogel to be used to treat second-degree burns that combined ciprofloxacin and lidocaine (CbCipLid hydrogel). Its antibiotic and anesthetic efficacy and the physical and chemical ...
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目录:
  • Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and „in’vivo evaluation in a second-degree burn model
    • Abstract
    • Introduction
    • Materials and methods
      • Preparation of the antibiotic-anesthetic hydrogel (CbCipLid hydrogel)
      • Stability of CbCipLid hydrogel
      • In’vitro release kinetics
      • Quantification of Cip and Lid by HPLC-UV
        • Instruments and analytical conditions
        • Calibration curves
        • Method validation
      • Rheological evaluation of CbCipLid hydrogel
      • Ethical protocols
      • In’vivo wound-healing test
      • Macroscopic examination
      • Histopathological study
      • CbCipLid hydrogel anesthetic effect
    • Results
      • Preparation of CbCipLid hydrogel
      • HPLC-UV method validation
      • In’vitro release kinetics
      • Rheological evaluation
      • In’vivo wound-healing test
      • CbCipLid hydrogel anesthetic effect
    • Discussion
    • References

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