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标题:Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver.
时间:2019-06-12 17:06:16
DOI:10.1186/s13148-017-0400-0
PMID:28947922
作者:Sonia GarcíaCalzón;Alexander Perfilyev;Ville Männistö;Vanessa D. de Mello;Emma Nilsson
出版源: 《Clinical Epigenetics》 ,2017 ,9 (1) :102
摘要:Diabetes medication associates with DNA methylation of metformin transporter genes in the human liverEpigeneticsDiabetes medicationMetforminOrganic cation transportersLiverType 2 diabetesGiven that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the...
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目录:
  • Abstract
    • Background
    • Results
    • Conclusions
  • Background
  • Results
  • Discussion
  • Conclusions
  • Methods
    • Study participants and clinical characteristics
    • DNA methylation analysis
    • Gene expression analysis
    • Cell culture experiments
    • Statistical analyses
  • Additional file
  • Abbreviations
  • Funding
  • Availability of data and materials
  • Authors’ contributions
  • Ethics approval and consent to participate
  • Consent for publication
  • Competing interests
  • Publisher’s Note
  • Author details
  • References

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