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标题:Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.
时间:2019-06-12 16:48:19
DOI:10.1186/s13148-018-0593-x
PMID:30545422
作者:Ilze Elbere;Ivars Silamikelis;Monta Ustinova;Ineta Kalnina;Linda Zaharenko
摘要:Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individualsBackground Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There......
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目录:
  • Abstract
    • Background
    • Results
    • Conclusions
    • Trial registration
  • Background
  • Results
    • Characteristics of the study participants
    • Differentially methylated CpGs
    • Differentially methylated regions (DMRs)
    • Enrichment analysis
  • Discussion
  • Conclusions
  • Methods
    • Study design
    • Sample analysis
    • Data preprocessing and statistical analysis
    • RNA-seq data analysis
  • Additional files
  • Abbreviations
  • Acknowledgements
  • Funding
  • Availability of data and materials
  • Authors’ contributions
  • Ethics approval and consent to participate
  • Consent for publication
  • Competing interests
  • Publisher’s Note
  • Author details
  • References

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