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标题:On efficient two-stage adaptive designs for clinical trials with sample size adjustment.
时间:2019-05-27 08:53:59
DOI:10.1080/10543406.2012.678226
PMID:22651105
作者:QingLiu;GangLi;KeavenM.Anderson;PilarLim
出版源: 《Journal of Biopharmaceutical Statistics》 ,2012 ,22 (4) :617-640
摘要:On Efficient Two-Stage Adaptive Designs for Clinical Trials with Sample Size AdjustmentAdaptation ruleCumulative conditional powerGroup sequential designsMedian unbiased estimatesMinimum variance unbiased estimatesSample size adjustmentSequential confidence intervalsSequential p-valuesTwo-stage adaptive designsGroup sequential designs are rarely used for clinical trials with substantial over ...
大小:297 kb
页数:26 PAGES
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