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标题:Study on the interaction between 4-thio-5-methyluridine and human serum albumin by spectroscopy and molecular modeling.
时间:2019-05-26 23:42:55
DOI:10.1016/j.saa.2013.11.113
PMID:24374886
作者:Zhang X;Zhai H;Gao R;Zhang J;Zhang Y
出版源: 《Spectrochimica Acta Part A Molecular & Biomole... ,2014 ,121 (5) :724-731
摘要:Study on the interaction between 4-thio-5-methyluridine and human serum albumin by spectroscopy and molecular modeling4-Thio-5-methyluridineHuman serum albumin (HSANucleosideFluorescence spectroscopyMolecular modelingThe interaction between 4-thio-5-methyluridine and human serum albumin (HSA) under simulative physiological conditions has been studied by the methods of fluorescence,...
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目录:
  • Study on the interaction between 4-thio-5-methyluridine and human serum albumin by spectroscopy and molecular modeling
    • Introduction
    • Experimental section
      • Materials and apparatus
      • Interaction between 4-thio-5-methyluridine and human serum albumin (HSA)
        • UV absorption spectroscopy experiments
        • Fluorescence spectroscopy experiments
        • Circular dichroism spectra
      • Molecular modeling study
    • Results and discussion
      • Ultraviolet absorption spectrum of the interaction between 4-thio-5-methyluridine and HSA
      • Fluorescence spectrum of the interaction between 4-thio-5-methyluridine and HSA
      • Quenching mechanism
        • Quenching constant of 4-thio-5-methyluridine and HSA
        • The binding constants of 4-thio-5-methyluridine and HSA
        • The binding modes of 4-thio-5-methyluridine and HSA
      • The 4-thio-5-methyluridine impact on the HSA
      • Circular dichroism of 4-thio-5-methyluridine and HSA
      • Binding distance
      • Molecular modeling study of the interaction between HSA and 4-thio-5-methyluridine
      • The comparison of interaction between HSA and 5-methyluridine/4-thio-5-methyluridine
        • The comparison o thermodynamic parameters
        • The comparison of molecules docking
    • Conclusion
    • Acknowledgments
    • References

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