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标题:miR-338 modulates proliferation and autophagy by PI3K/AKT/mTOR signaling pathway in cervical cancer.
时间:2019-05-16 23:08:03
DOI:10.1016/j.biopha.2018.06.024
PMID:29898430
作者:Lu R;Yang Z;Xu G;Yu S
出版源: 《Biomedicine & Pharmacotherapy》 ,2018 ,105 :633
摘要:In summary, our study demonstrate that miR-338 could inhibites proliferation and autophagy by targeting ATF2 via mTOR signaling pathway on cervical cancer cells. These results suggest a potential application of miR-338 in cervical cancer...
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目录:
  • miR-338 modulates proliferation and autophagy by PI3K/AKT/mTOR signaling pathway in cervical cancer
    • Introduction
    • Materials and methods
      • Tissue samples and cell culture
      • Quantitative real-time PCR
      • Western blotting
      • Cell proliferation assay
      • Cell cycle analysis
      • Cell migration and invasion assays
      • TUNEL assays
      • GFP-LC3 translocation
      • Luciferase assay
      • Statistical analysis
    • Results
      • miR-338 is down-regulated in cervical cancer tissues and cell lines
      • Inhibition of miR-338 promotes cell proliferation in cervical cancer cells
      • Effects of miR-338 on cervical cancer cell cycle
      • Effect of miR-338 on invasion and apoptosis in CC cell
      • miR-338 inhibits autophagy in cervical cancer cells
      • miR-338 targets ATF2 in cervical cancer cells
      • miR-338 inhibits autophagy by PI3K/AKT/mTOR signaling pathway in cervical cancer cells
    • Discussion
    • Conclusion
    • Conflict of interests
    • Acknowledgment
    • References

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