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标题:Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09.
时间:2019-05-16 23:05:19
DOI:10.1016/j.jcv.2013.05.011
PMID:23790455
作者:Bradley-Stewart A;Jolly L;Adamson W;Gunson R;Frew-Gillespie C
出版源: 《Journal of Clinical Virology the Official Publ... ,2013 ,58 (1) :100-107
摘要:Influenza virus affects millions of people worldwide each year. More severe infection occurs in the elderly, very young and immunocompromised. In 2009, a n...
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目录:
  • Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09
    • 1 Background
    • 2 Objectives
    • 3 Study design
      • 3.1 Clinical samples
      • 3.2 Multiplex bead immunoassay
      • 3.3 Assays for serum concentrations of ST2 and IL-33
      • 3.4 Total protein concentration
      • 3.5 Statistical analysis
    • 4 Results
      • 4.1 Study group demographics
      • 4.2 Cross-sectional study
        • 4.2.1 Comparison of serum cytokine concentrations between the four patient groups
        • 4.2.2 Pairwise comparison of serum cytokine concentrations
        • 4.2.3 Healthy controls versus rhinovirus
        • 4.2.4 Mild influenza A(H1N1)pdm09 virus versus rhinovirus
        • 4.2.5 Severe influenza A(H1N1)pdm09 virus versus rhinovirus
        • 4.2.6 Mild influenza A(H1N1)pdm09 virus versus healthy blood donors
        • 4.2.7 Severe influenza A(H1N1)pdm09 virus versus healthy blood donors
        • 4.2.8 Mild influenza A(H1N1)pdm09 virus versus severe influenza A(H1N1)pdm09 virus
      • 4.3 Longitudinal study
        • 4.3.1 Serum samples
        • 4.3.2 Respiratory samples
    • 5 Discussion
    • Funding
    • Competing interests
    • Ethical approval
    • References

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