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标题:Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.
时间:2019-05-16 10:49:51
DOI:10.1016/j.bbr.2015.05.002
PMID:25975173
作者:Kemppainen S;Lindholm P;Galli E;Lahtinen HM;Koivisto H
出版源: 《Behavioural Brain Research》 ,2015 ,291 :1-11
摘要:Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. Behav...
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目录:
  • Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice
    • 1 Introduction
    • 2 Methods
      • 2.1 Animals
      • 2.2 Protein production and viral vectors
      • 2.3 Intrahippocampal administration of treatments
      • 2.4 Behavioral testing
      • 2.5 Immunohistochemistry
      • 2.6 Protein assays
      • 2.7 Quantitative RT-PCR
      • 2.8 Statistics
    • 3 Results
      • 3.1 Expression of hCDNF in APP/PS1-mice
      • 3.2 CDNF treatment improves spatial long-term memory
      • 3.3 CDNF-transduction efficiency correlates with long-term memory
      • 3.4 CDNF-treatment increases object exploration
      • 3.5 CDNF treatment has no undesirable side effects on general behavior
      • 3.6 CDNF has no effect on adult neurogenesis
      • 3.7 CDNF has no effect on amyloid plaque burden in APP/PS1 mice
      • 3.8 CDNF has little effect on hippocampal dopamine innervation
      • 3.9 CDNF effect on hippocampal synaptophysin levels is genotype dependent
    • 4 Discussion
    • 5 Conclusion
    • Acknowledgement
    • References

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