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标题:Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.
时间:2019-05-16 10:43:03
DOI:10.1016/j.ijantimicag.2014.07.001
PMID:25216547
作者:Luque S;Grau S;AlvarezLerma F;Ferrández O;Campillo N
出版源: 《International Journal of Antimicrobial Agents》 ,2014 ,44 (5) :409-415
摘要:Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections....
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目录:
  • Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspect...
    • 1 Introduction
    • 2 Materials and methods
      • 2.1 Study design and population
      • 2.2 Plasma and cerebrospinal fluid sample collection
      • 2.3 Bioanalysis
      • 2.4 Population pharmacokinetic analysis
        • 2.4.1 Population pharmacokinetic model diagnostics
        • 2.4.2 Population pharmacokinetic covariate screening
        • 2.4.3 Population pharmacokinetic bootstrap
      • 2.5 Other pharmacokinetic calculations
      • 2.6 Assessment of pharmacodynamics and efficacy thresholds
      • 2.7 Statistical analysis
    • 3 Results
      • 3.1 Pharmacokinetic model building
    • 4 Discussion
    • References

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