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标题:Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats.
时间:2019-04-16 00:51:25
DOI:10.1016/j.freeradbiomed.2012.11.002
PMID:23146767
作者:Kara A;Akman S;Ozkanlar S;Tozoglu U;Kalkan Y
出版源: 《Free Radic Biol Med》 ,2013 ,55 (1) :21-26
摘要:Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats.INDUCED DIABETIC-RATSADULT PERIODONTITISFREE-RADICALSORAL-CAVITYDNA-DAMAGEDISEASECELLEXPRESSIONMODELAPOPTOSISMelatonin is an important antioxidant, and through its anti-inflammatory effects it can control immune responses, oxidative stress, and defense cell infiltration. Periodontitis is a disease ...
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目录:
  • Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats
    • Material and methods
      • Animals and housing
      • Animal periodontitis model
      • Drug administration and analysis
      • Sample collection and biochemical assays
      • Assay of 8-OHdG levels
      • Serum IL-1beta and TNF-alpha levels analysis
      • Serum melatonin analysis by HPLC
      • Histochemical analysis
      • Statistical analysis
    • Results
      • Biochemical results
      • Serum melatonin level
      • Serum IL-1beta and TNF-alpha levels
      • 8-OHdG level
      • Histopathological results
    • Discussion
    • Acknowledgments
    • References

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