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标题:Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction.
时间:2019-04-15 23:05:59
DOI:10.1016/j.gene.2018.06.068
PMID:29936266
作者:Jingtao Wang;Baodong Zhao;Shimao Yang;Dashan Wang;Hao Xu
出版源: 《Gene》 ,2018 :S037811191830725X-
摘要:Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 inductionIn the current study, we aimed to examine the function of scutellarin on human osteoblast proliferation and osteogenic function. The results indicated...
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目录:
  • Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction
    • Introduction
    • Material and methods
      • Cell culture
      • Cell proliferation assay
      • Ponceau S assay
      • Alkaline phosphatase (ALP) assay
      • Intracellular calcium assay
      • Calcium deposition assay
      • Reverse transcription and quantitative RT–PCR
      • Western blotting
      • CXCR4 and p65 silencing
      • ChIP assay
      • CXCR4 promoter luciferase reporter assay
      • Ovariectomized rat model
      • Statistical analyses
    • Results
      • Effects of scutellarin on human osteoblast function
      • Scutellarin up-regulated CXCR4 expression in osteoblasts
      • Effects of CXCR4 knockdown on osteoblast proliferation and function
      • Scutellarin enhanced p65 phosphorylation and the subsequent binding to the CXCR4 promoter
      • p65 inactivation blocked scutellarin-induced osteoblast function
      • Scutellarin increased bone microarchitecture in an OVX rat model
    • Discussion
    • Conflicts of interest
    • Founding
    • Authors' contributions
    • Acknowledgements
    • References

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