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标题:Cross-talk between TNF-α and IFN-γ signaling in induction of B7-H1 expression in hepatocellular carcinoma cells.
时间:2019-04-15 22:11:45
DOI:10.1007/s00262-017-2086-8
PMID:29090321
作者:Na Li;Jianing Wang;Na Zhang;Mengwei Zhuang;Zhaoyun Zong
出版源: 《Cancer Immunology Immunotherapy》 ,2017 ,67 (9) :1-13
摘要:Cross-talk between TNF-α and IFN-γ signaling in induction of B7-H1 expression in hepatocellular carcinoma cellsClinical benefit from immunotherapy of B7-H1/PD-1 checkpoint blockade indicates that it is important to understand the ...
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页数:14 PAGES
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目录:
  • Cross-talk between TNF-α and IFN-γ signaling in induction of B7-H1 expression in hepatocellular carcinoma cells
    • Abstract
    • Introduction
    • Materials and methods
      • Cell culture and treatment
      • Signal transduction analysis
      • Small interfering RNA (siRNA) assay
      • Reverse transcription PCR (RT-PCR)
      • Flow cytometry
      • Western blot
      • Functional assay of B7-H1
      • Statistics
    • Results
      • IFN-γ induced the expression of B7-H1 on the HCC cells
      • The induction of B7-H1 expression by IFN-γ was dependent of JAKSTAT1 signaling pathway
      • The synergy of IFN-γ and TNF-α in the induction of B7-H1 expression in the HCC cells
      • The mechanism of the synergy of TNF-α and IFN-γ in induction of B7-H1 expression in the HCC cells was that the TNF-α enhanced the IFN-γ signaling
      • B7-H1 expression induced by the combination of TNF-α and IFN-γ in mouse HCC cells contributed to promotion of tumor growth in vivo
    • Discussion
    • References

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