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标题:The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice.
时间:2019-04-15 22:08:19
DOI:10.1186/s11658-018-0122-0
PMID:30564277
大小:1725 kb
页数:12 PAGES
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目录:
  • Abstract
    • Objective
    • Methods
    • Results
    • Conclusion
  • Introduction
  • Experimental materials and methods
    • Animals and tumor cell lines
    • Modeling tumor-bearing mice
    • Introduction of siRNA
    • Observing the physiological condition of the H22 mice
    • Determining the levels of IFN-γ, IL-10 and PD-L1
    • Determining the mRNA levels of IFN-γ, PD-1, CTLA-4, Survivin and, IL-6
    • Determining the expressions of Bax and Bcl-2
    • Statistical analysis
  • Results
    • Physiological observations
    • The inhibitory effect of siRNA on the tumor
    • The effect of siRNA on IFN-γ, IL-10 and PD-L1 levels in the blood and tissue
    • The effect of siRNA onthe mRNA of IFN-γ, PD-L1, PD-1, CTLA-4, IL-6 and Survivinin the tissue
    • The effect of siRNA on Bax and Bcl-2 in the tumor
  • Discussion
  • Conclusions
  • Abbreviations
  • Acknowledgements
  • Funding
  • Availability of data and materials
  • Authors’ contributions
  • Ethics approval
  • Consent for publication
  • Competing interests
  • Publisher’s Note
  • Author details
  • References

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