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时间:2019-04-15 22:00:56
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目录:
  • Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model
    • Introduction
    • Materials and methods
      • Mice
      • IP administration of CCl4, intrasplenic injection of hepatocytes and magnetic resonance imaging (MRI)
      • Flow cytometric analysis
      • In vivo T cell receptor (TCR)-I T cell proliferation assay
      • Capturing and immunostaining of circulating tumor cells
      • Histologic staining and immunohistochemistry (IHC)
      • Sunitinib and anti-PD-1 administration, adoptive cell transfer, and immunization
      • Statistics
    • Results
      • Establishment of a clinically relevant murine model with typical features of human HCC
      • Shift of anti-tumor immunity from ignorance to tolerance with progression from early-stage to advanced stage tumors
      • Migration of tumor cells to draining lymph nodes and their circulation in the blood are associated with immune tolerance in late-stage tumor-bearing mice
      • Upregulation of inhibitory immune checkpoints and increase of Tregs are associated with exhaustion of effector CD8+ T cells in late-stage tumor development
      • Combination of sunitinib and anti-PD1 antibody strikingly suppresses tumor growth and powerfully activates TAS anti-tumor immunity
    • Discussion
    • Financial support
    • Conflict of interest
    • Authors’ contributions
    • Acknowledgements
    • Supplementary data
    • Supplementary data
    • References
      • Author names in bold designate shared co-first authorship

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