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标题:Intestinal cholecystokinin controls glucose production through a neuronal network.
时间:2019-04-15 21:33:19
DOI:10.1016/j.cmet.2009.07.005
PMID:19656488
作者:Grace W.C. Cheung;Andrea Kokorovic;Carol K.L. Lam;Madhu Chari;Tony K.T. Lam
出版源: 《Cell Metabolism》 ,2009 ,10 (2) :99-109
摘要:Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of ...These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to...
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目录:
  • Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network
    • Introduction
    • Results
      • Duodenal CCK Activates CCK-A Receptors to Lower Glucose Production
      • Duodenal CCK Fails to Lower Glucose Production in CCK-A Receptor-Deficient Rats
      • Duodenal CCK Activates a Gut-Brain-Liver Axis to Lower Glucose Production
      • Duodenal CCK-A Receptors Are Required for Lipids to Lower Glucose Production
      • Pharmacological and Molecular Inhibition of CCK-A Receptors Disrupts Glucose Homeostasis during Refeeding
      • Duodenal CCK Fails to Lower Glucose Production in Response to High-Fat Feeding
    • Discussion
    • Experimental Procedures
      • Chemicals
      • Animal Preparation
        • Male Spague-Dawley Rats
        • Male LETO/OLETF Rats
        • Duodenal and Intravenous Cannulations
        • Stereotaxic Surgery
        • Selective Hepatic Branch Vagotomy
      • Clamp Procedure
      • Intraduodenal Infusions and Treatments
      • Fasting-Refeeding Experiment
      • High-Fat Feeding in Male SD Rats
      • Peripheral and Portal CCK Measurements
      • Biochemical Analysis
      • Calculations
    • Supplemental Data
    • Acknowledgments
    • References

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