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标题:Plasminogen activator inhibitor 2 (PAI2) inhibits invasive potential of hepatocellular carcinoma cells in vitro via uPA- and RB/E2F1-related mechanisms.
时间:2019-03-15 13:44:11
DOI:10.1007/s12072-018-9920-8
PMID:30600477
作者:Ye Jin;Zhi-Yong Liang;Wei-Xun Zhou;Li Zhou
出版源: Hepatology International ,2019
摘要:Plasminogen activator inhibitor 2 (PAI2) inhibits invasive potential of hepatocellular carcinoma cells in vitro via uPA- and RB/E2F1-related mechanismsBackground Plasminogen activator inhibitor 2 (PAI2) has been shown to be associated with...
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目录:
  • Plasminogen activator inhibitor 2 (PAI2) inhibits invasive potential of hepatocellular carcinoma cells in vitro via uPA- and RBE2F1-related mechanisms
    • Abstract
      • Background
      • Methods
      • Results
      • Conclusions
    • Introduction
    • Materials and methods
      • Establishment of PAI2 stably overexpressed and silenced sub-lines, and transient overexpression of E2F1
      • Real-time reverse transcription-polymerase chain reaction (RT-PCR)
      • Western blotting
      • Wound-healing assay
      • Transwell invasion analysis
      • Cell proliferation assay
      • Measurement of uPA activity in the cell medium
      • Patients, tissue microarray construction and immunohistochemistry
      • Statistical analyses
    • Results
      • Successful establishment of PAI2 stably overexpressed and silenced sub-lines
      • PAI2 inhibits migration and invasion of HCC cells
      • PAI2 inhibits uPA activity and increases RB protein expression in HCC cells
      • Transient overexpression of E2F1 reverses PAI2-mediated inhibition of migration and invasion of HCC cells
      • E2F1 is overexpressed in HCC and predicts poor prognosis
    • Discussion
    • Conclusions
    • Acknowledgements
    • References

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