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标题:Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation.
时间:2019-03-15 10:33:04
DOI:10.1016/j.jdermsci.2013.06.007
PMID:23870655
作者:Tarutani M;Nakajima K;Takaishi M;Ohko K;Sano S
出版源: 《Journal of Dermatological Science》 ,2013 ,72 (2) :110-115
摘要:Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation.Epidermal hyperplasiaRafStat3Transgenic miceKnockout miceRaf is one of the downstream effectors of Ras GTPases, and plays a key role in regulating cell proliferation and differentiation through the activation of MAPK. We have previously demonstrated that temporal induction of Raf in the epidermis of ...
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目录:
  • Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation
    • Introduction
    • Materials and methods
      • Mice
      • Histology and immunohistochemistry
      • RNA isolation and real time PCR
      • Western blot analysis
      • Statistical analysis
    • Results and discussion
      • Nuclear Erk1/2 MAPK and phosphorylated Stat3 are co-localized in psoriatic lesion
      • Phosphorylated-Stat3 was found in Raf-induced psoriasis-like hyperplastic epidermis
      • Stat3 deficiency inhibited generation of Raf-induced psoriasis-like skin hyperplasia
      • Change in the down-stream molecules by Stat3 deletion in Raf-induced epidermal change
    • Acknowledgements
    • References

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