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标题:Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
时间:2019-03-14 23:49:48
DOI:10.1021/jm060257t
PMID:16722663
作者:Sandra Gemma,†,‡;Emanuele Gabellieri,†,‡;Paul Huleatt,†;Caterina Fattorusso,‡,§;Marianna Borriello,‡,§
出版源: 《Journal of Medicinal Chemistry》 ,2006 ,49 (11) :3421-5
摘要:Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.fluorine-18synthesispenciclovirradiofluorinationWe describe herein the development of novel huperzine A-tacrine hybrids characterized by 3-methylbicyclo[3.3.1]non-3-ene scaffolds. These compounds were specifically designed to establish tight interactions, ...
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