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标题:Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells.
时间:2019-02-12 00:19:35
DOI:10.1016/j.febslet.2005.06.051
PMID:16051220
作者:Carles Lozanoa;Josep Llu´ıs Torresb;Llu´ıs Julia`b;Aurora Jimenezb;Josep Joan Centellesa
出版源: 《Febs Letters》 ,2005 ,579 (20) :4219-25
摘要:Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells.catechinsantioxidantsgallate estermelanomacell cycleapoptosisNovel catechin derivatives obtained from grape procyanidins and l-cysteine scavenge free radicals by hydrogen atom donation, rather than electron transfer, and reduce cell viability in A375 and M21 melanoma cells. In particular, 4beta-(S-...
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目录:
  • Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells
    • Introduction
    • Materials and methods
      • Electron transfer assay
      • Cell culture
      • Growth inhibition assay
      • Cell cycle analysis
      • Assessment of apoptosis
      • DNA fragmentation assay
      • Statistics
    • Results and discussion
      • Free radical scavenging activity. Hydrogen donation versus electron transfer
      • Growth inhibition capacity
      • Cell cycle analysis and apoptosis induction
      • Detection of fragmented DNA by agarose gel electrophoresis
    • Acknowledgements
    • References

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