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标题:An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasma.
时间:2019-02-11 20:22:39
DOI:10.1016/j.jpba.2016.06.039
PMID:27411171
作者:Shaheed Ur Rehman;Min Sun Choi;In Sook Kim;Seung Hyun Kim;Hye Hyun Yoo
出版源: 《Journal of Pharmaceutical & Biomedical Analysis》 ,2016 ,129 :90-95
摘要:An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasmaHederacoside CHedera helixUPLC–MS/MSPlasmaPharmacokineticsHederacoside C is a principal bioactive pharmaceutical ingredient ofHedera helixleafextracts.H. helixextracts have long been used in folk ...
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目录:
  • An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, ...
    • 1 Introduction
    • 2 Materials and methods
      • 2.1 Chemicals and reagents
      • 2.2 H. helix extract
      • 2.3 Preparation of calibration standards and quality control (QC) samples
      • 2.4 Sample preparation
      • 2.5 LC–MS/MS condition
      • 2.6 Method validation
      • 2.7 Pharmacokinetic study in rats
      • 2.8 Pharmacokinetic analysis
    • 3 Results and discussion
      • 3.1 Analytical method validation
        • 3.1.1 Specificity
        • 3.1.2 Linearity and LLOQ
        • 3.1.3 Accuracy and precision
        • 3.1.4 Extraction recovery and matrix effect
        • 3.1.5 Stability
        • 3.1.6 Dilution integrity
      • 3.2 Application of the pharmacokinetic study

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