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标题:Single-center, single-dose, open-label, randomized, two-period crossover study on the bioavailability of methotrexate administered using a novel prefilled, needle-free delivery system.
时间:2019-02-11 17:45:55
DOI:10.1080/03007995.2016.1263611
PMID:27874307
作者:Bienvenu B;Aouba A;Gottenberg JE;Verstuyft C
出版源: 《Current Medical Research & Opinion》 ,2016 ,33 (4) :605-611
摘要:Objective: Zeneo1 is a needle-free injection device. We performed a pharmacokinetic study to investigate the bioequivalence of methotrexate administered su...
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目录:
  • Single-center, single-dose, open-label, randomized, two-period crossover study on the bioavailability of methotrexate administered using a novel prefilled, needle-free delivery system
    • Introduction
    • Patients and methods
      • Study design
      • Study participants
      • Treatments administered
      • Pharmacokinetic assessment
      • Bioanalytical method
      • Safety and tolerability variables
      • Statistical analysis
    • Results
      • Study participants
      • Pharmacokinetic analysis
      • Safety and tolerability
    • Discussion
    • Conclusion
    • Transparency
    • Declaration of funding
    • Declaration of financial/other relationships
    • Acknowledgments
    • References

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