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标题:Inhibition of integrin α5β1 ameliorates VEGF-induced retinal neovascularization and leakage by suppressing NLRP3 inflammasome signaling in a mouse model.
时间:2019-02-11 17:51:02
DOI:10.1007/s00417-018-3940-x
PMID:29502235
大小:9950 kb
页数:12 PAGES
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目录:
  • Inhibition...
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Introduction
    • Materials and methods
      • Reagents
      • Animals
      • Quantitative reverse transcription polymerase chain reaction (RT-PCR)
      • Western blot analysis
      • Frozen section analysis
      • Immunofluorescence staining
      • Cell culture and stimulation
      • Statistical analysis
    • Results
      • Integrin α5β1 expression was increased in adult Tet/opsin/VEGF transgenic mice treated with doxycycline
      • ATN-161 inhibited integrin α5β1 expression in adult Tet/opsin/VEGF transgenic mice treated with doxycycline
      • Inhibiting integrin α5β1 by ATN-161 ameliorated retinal detachment of Tet/opsin/VEGF transgenic mice
      • NLRP3 inflammasome expression increased in adult Tet/opsin/VEGF transgenic mice with doxycycline treatment
      • ATN-161 reduced NLRP3 inflammasome activation in adult Tet/opsin/VEGF transgenic mice
      • ATN-161 reduced NLRP3 inflammasome activation in HRECs treated with VEGF
    • Discussion
    • Conclusion
    • References

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