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标题:Subcutaneous semaglutide (NN9535) for the treatment of type 2 diabetes.
时间:2019-02-11 15:58:32
DOI:10.1080/14712598.2018.1439014
PMID:29431519
作者:Maka S Hedrington;Ana Tsiskarishvili;Stephen N Davis
出版源: 《Expert Opinion on Biological Therapy》 ,2018 ,18 (3)
摘要:Subcutaneous semaglutide (NN9535) for the treatment of type 2 diabetesIntroduction: This manuscript describes 21 drug targets in the area of diabetes and related conditions that were discontinued in 2015. Areas covered: The material for this paper was obtained by contacting biopharmaceutical companies, reviewing their pipelines, press releases and annual reports. Additionally, ...
大小:1195 kb
页数:11 PAGES
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目录:
  • Abstract
  • 1. Introduction
  • 2. Structure and chemistry
  • 3. Clinical development of semaglutide
    • 3.1. Phase 1 trials
      • 3.1.1. QTc
      • 3.1.2. Drug interactions
      • 3.1.3. Gastric emptying
    • 3.2. Phase 2 trial
    • 3.3. Phase 3 trials
    • 3.4. Safety and tolerability
  • 4. Regulatory affairs
  • 5. Expert opinion
  • Declaration of interest
  • References

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