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标题:T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway.
时间:2019-01-12 00:50:32
DOI:10.1007/s00210-017-1413-0
PMID:28785775
作者:Jumpei Yasuda;Kana Fukui;Muneyoshi Okada;Hideyuki Yamawaki
出版源: Naunyn-Schmiedeberg's Archives of Pharmacology ,2017 ,390 (11) :1135-1144
摘要:Proliferation and migration of cardiac fibroblasts are important in early stage of wound-healing after myocardial infarction. The effects of tumstatin, a cleaved fragment of collagen type IV α3 chain,
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目录:
  • T3...
    • Abstract
    • Introduction
    • Materials and methods
      • Reagents and antibodies
      • Primary culture of cardiac fibroblasts
      • Cell proliferation assay
      • Boyden chamber assay
      • Western blotting
      • Myocardial infarction model
      • Statistical analysis
    • Results
      • T3 peptide stimulated proliferation of adult rat cardiac fibroblasts
      • T3 peptide stimulated migration of adult rat cardiac fibroblasts
      • T3 peptide increased Akt phosphorylation in adult rat cardiac fibroblasts
      • Inhibition of PI3K/Akt signaling suppressed T3 peptide-induced proliferation and migration of adult rat cardiac fibroblasts
      • T3 peptide activated p70S6K, a downstream of Akt signaling pathway in adult rat cardiac fibroblasts
      • Inhibition of integrin αvβ3/αvβ5 suppressed T3 peptide-induced phosphorylation of Akt and proliferation of adult rat cardiac fibroblasts
      • Expression of tumstatin decreases in the infarcted area of rat model of myocardial infarction
    • Discussion
    • References

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