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标题:Role of Pin1 in UVA-induced cell proliferation and malignant transformation in epidermal cells.
时间:2019-01-11 22:50:56
DOI:10.1016/j.bbrc.2011.05.106
PMID:21640077
作者:Chang Yeob Han;Tran Thi Hien;Sung Chul Lim;Keon Wook Kang
出版源: 《Biochemical & Biophysical Research Communicati... ,2011 ,410 (1) :68-74
摘要: Volume 410, Issue 1, 24 June 2011, Pages 68–74 Role of Pin1 in UVA-induced cell proliferation and malignant transformation in epidermal cells Chang Yeob Hana, Tran Thi Hiena,...Here, we demonstrated that Pin1 expression was enhanced by low energy UVA (300–900 mJ/cm2) irradiation in both skin tissues of hairless mice and JB6 C141 epidermal cells. ...
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目录:
  • Role of Pin1 in UVA-induced cell proliferation and malignant transformation in epidermal cells
    • 1 Introduction
    • 2 Materials and methods
      • 2.1 Materials
      • 2.2 Cell culture and UVA irradiation
      • 2.3 Immunoblot analysis and immunohistochemistry
      • 2.4 Reporter gene assay
      • 2.5 MTT assay
      • 2.6 Colony formation assay
      • 2.7 Data analysis
    • 3 Results
      • 3.1 Increase in Pin1 expression by UVA in both JB6 Cl41 epidermal cells and skin tissues of hairless mice
      • 3.2 Role of Pin1 in UVA-induced cyclin D1 expression, cell proliferation and malignant transformation
      • 3.3 Involvement of Pin1 in UVA-stimulated AP-1 activation
      • 3.4 Role of ROS in UVA-induced Pin1 expression
    • 4 Discussion
    • Acknowledgment
    • References

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