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标题:The genetic and molecular basis of Fanconi anemia.
时间:2019-01-11 20:44:35
DOI:10.1016/j.mrfmmm.2008.11.004
PMID:19061902
作者:de Winter JP;Joenje H
出版源: Mutation Research ,2009 ,668 (1-2) :11-19
摘要:The capacity to maintain genomic integrity is shared by all living organisms. Multiple pathways are distinguished that safeguard genomic stability, most of...
大小:697 kb
页数:10 PAGES
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目录:
  • The genetic and molecular basis of Fanconi anemia
    • Introduction
    • DNA cross-linker sensitivity, an important hallmark for FA cells
    • Complementation group D, the first link between FA and DNA repair
    • Multiple FA proteins act in a nuclear core complex
    • FANCJ, a helicase downstream or independent of FANCD2
    • PALB2/FANCN, another FA protein identified by protein association
    • FANCI, the monoubiquitinated partner of FANCD2
    • A model for the FA/BRCA pathway
    • Conflict of interest statement
    • Acknowledgements
    • References

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