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标题:Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo.
时间:2019-01-11 18:48:40
DOI:10.1016/j.steroids.2013.07.003
PMID:23891646
作者:Zhang R;Huang B;Du D;Guo X;Xin G
出版源: 《Steroids》 ,2013 ,78 (11) :1064-1070
摘要:Thrombosis in coronary or cerebral arteries is the major cause of morbidity and mortality worldwide. Diosgenin and total steroidal saponins extracted from ...
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目录:
  • Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo
    • 1 Introduction
    • 2 Experimental
      • 2.1 Chemistry
        • 2.1.1 Material and instrument
        • 2.1.2 Diosgenyl 2,3,4,6-tetra-O-acetyl-β-d-galac
        • 2.1.3 Diosgenyl β-d-galactopyranosyl-(1→4)-β-d-g
      • 2.2 Biological activities
        • 2.2.1 Materials and animals
        • 2.2.2 Bleeding time assay
        • 2.2.3 Blood preparation
        • 2.2.4 Platelet aggregation assay in vivo and in vitro
        • 2.2.5 Anticoagulation activity assay
        • 2.2.6 Protective effect on mice with pulmonary thromboembolism
      • 2.3 Statistical analysis
    • 3 Results
      • 3.1 Design and synthesis of diosgenyl β-d-galact
      • 3.2 Compound 3 significantly increase bleeding time in mice
      • 3.3 Compound 3 directly inhibit platelet aggregation in vivo and in vitro
      • 3.4 Compound 3 prolongs coagulation time selectivity and inhibits factor VIII activities
      • 3.5 Compound 3 protects mice with pulmonary thromboembolism
    • 4 Discussion
    • Acknowledgments
    • Appendix A Supplementary data
    • References

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