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标题:Metabolism and transport of oxazaphosphorines and the clinical implications.
时间:2018-12-07 11:14:27
DOI:10.1080/03602530500364023
PMID:16393888
作者:Zhang J;Tian Q;Yung Chan S;Chuen Li S;Zhou S
出版源: 《Drug Metabolism Reviews》 ,2005 ,37 (4) :611
摘要:This review highlights the metabolism and transport of these oxazaphosphorines (mainly CPA and IFO, as these two oxazaphosphorine drugs are the most widely used alkylating agents) and the clinical implications. Both CPA and IFO are prodrugs that require activation by hepatic cytochrome P450 (CYP)-catalyzed 4-hydroxylation, yielding cytotoxic nitrogen mustards capable of ...
大小:851 kb
页数:95 PAGES
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