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标题:Cdc25: mechanisms of checkpoint inhibition and recovery.
时间:2018-12-07 03:11:35
DOI:10.1016/j.tcb.2006.04.002
PMID:16682204
作者:Christina Karlsson-Rosenthal;Jonathan B.A. Millar
出版源: 《Trends in Cell Biology》 ,2006 ,16 (6) :285-292
摘要:Members of the eukaryotic Cdc25 phosphatase family are key targets of the Chk1 and Chk2 checkpoint kinases, which inactivate Cdc25 to halt cell cycle progression when DNA is damaged or incompletely replicated. Now, new kinases that phosp...
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目录:
  • Cdc25: mechanisms of checkpoint inhibition and recovery
    • Introduction
    • DNA structure checkpoints target Cdc25
    • Stress-activated p38 MAPK inhibits Cdc25 through activation of MAPKAPK-2
    • Regulation of Cdc25 by members of the CAMK protein kinase family
    • Amplification of Cdc25 activity
    • Role of the spindle poles in mitotic entry
    • Cdc25B and Polo kinase are required for checkpoint recovery
    • Concluding remarks
    • Acknowledgements
    • References

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