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标题:Micelles with ultralow critical micelle concentration as carriers for drug delivery
时间:2018-11-09 00:43:34
DOI:10.1038/s41551-018-0234-x
作者:Yang Lu;Zhanguo Yue;Jinbing Xie;Wei Wang;Hui Zhu
摘要:Micelles with ultralow critical micelle concentration as carriers for drug deliveryl -CarnitineMA is the first zwitterionic betaine monomer from natural feedstocks, exhibiting superior anti-fouling performance.doi:10.1038/s41551-018-0234-xYang LuZhanguo YueJinbing XieWei WangHui ZhuErshuai ZhangZhiqiang Cao...
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目录:
  • Micelles with ultralow critical micelle concentration as carriers for drug delivery
    • Micelle-forming DSPE-PCB 5K.
    • Conventional methods cannot determine an ultralow CMC.
    • Verification of a new method to determine the CMC.
    • DSPE-PCB 5K has an undetectable ultralow CMC.
    • Zwitterionic PCB and its amount are critical to achieving the ultralow-CMC property.
    • Ultrastability of ultralow-CMC micelles when diluted in serum.
    • Drastically increased antitumour performance of docetaxel ­stabilized by ultralow-CMC micelles.
    • Methods
      • Materials
      • Preparation of gold NPs encapsulated by DSPE-PCB 5K
      • Preparation of the docetaxel/DSPE-PCB 5K formulation
      • Animal experiments
      • Statistical analysis
      • Reporting Summary
      • Data availability
    • Acknowledgements
    • Author contributions
    • Fig. 1 Ultralow-CMC micelles and their unusual ability to stabilize cargoes in extremely diluted conditions with micelle concentrations far below the CMC of conventional micelles.
    • Fig. 2 TEM and DLS measurements for DSPE-PCB 5K micelles.
    • Fig. 3 Diluting–concentrating method to probe CMCs for micelles.
    • Fig. 4 Effect of supplying zwitterionic moieties on the CMC of conventional micelles, and impact of the zwitterionic PCB MW on the CMC of DSPE-PCB.
    • Fig. 5 Stability of ultralow-CMC micelles and conventional micelles with gold NP probes encapsulated at a 5.
    • Fig. 6 Stability of docetaxel/DSPE-PCB 5K formulation and its antitumour performance compared with control formulations.

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