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标题:NAD(+) administration decreases doxorubicin-induced liver damage of mice by enhancing antioxidation capacity and decreasing DNA damage.
时间:2018-10-11 17:45:34
DOI:10.1016/j.cbi.2014.01.013
PMID:24491677
大小:1476 kb
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目录:
  • NAD+ administration decreases doxorubicin-induced liver damage of mice by enhancing antioxidation capacity and decreasing DNA damage
    • 1 Introduction
    • 2 Materials and methods
      • 2.1 Materials
      • 2.2 Procedures of animal operation
      • 2.3 Assays of the activity of serum glutamate oxaloacetate transaminase (SGOT)
      • 2.4 GSH assay
      • 2.5 Caspase-3 activity assay
      • 2.6 TUNEL staining
      • 2.7 Immunostaining of activated capase-3
      • 2.8 Immunostaining of phosphohistone H2AX (γ-H2A
      • 2.9 NAD+ assay
      • 2.10 Glutathione reductase (GR) assay
      • 2.11 Real-time PCR
      • 2.12 Statistical analyses
    • 3 Results
      • 3.1 Effects of NAD+ administration on DOX-induced increases in SGOT activity and decreases in liver weight and body weight
      • 3.2 Effects of NAD+ administration on DOX-induced apoptotic changes of the liver
      • 3.3 Effects of NAD+ administration on DOX-induced dsDNA damage of the liver
      • 3.4 NAD+ administration significantly attenuated DOX-induced decreases in the NAD+ levels in the liver
      • 3.5 Effects of administration of NAD+ or NAC on DOX-induced decreases in the GSH levels in the liver of mice
    • 4 Discussion
    • Conflict of interest
    • Acknowledgment
    • Appendix A Supplementary data
    • References

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